trkA Receptor

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Also Known As:

Receptor, trkA; Neurotrophic Tyrosine Kinase Receptor Type 1; Proto-Oncogene Products c-trk; c-trk Protein; gp140 c-trk; p140-trkA; trk1 Transforming Tryrosine Kinase; Proto Oncogene Products c trk; Proto Oncogene Protein trk; Proto-Oncogene Protein, trk; Receptor, NTRK1; c trk Protein; c-trk, Proto-Oncogene Products; c-trk, gp140; gp140 c trk; p140 trkA; trk Proto Oncogene Protein; trk, Proto-Oncogene Protein; NTRK1 Receptor; Proto-Oncogene Protein trk; Receptor, Neurotrophic Tyrosine Kinase Type 1; gp140(c-TRK); trk Proto-Oncogene Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        trkA Receptor: 143
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        trkA Receptor: 143
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Nerve Growth Factor Receptors: 526
        trkA Receptor: 143
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        trkA Receptor: 143

Margus Lopp Selected Research

Margus Lopp Research Topics

Disease

Drug/Important Bio-Agent (IBA)